Presently, there is no such thing as a particular, direct-acting antagonist to counteract the consequences of ketamine. Administration of hostile results focuses on supportive care. This entails making certain enough air flow, sustaining cardiovascular stability, and managing any emergent psychological disturbances. The first goal is to deal with the signs introduced by the person moderately than reversing the drug’s motion instantly.
Supportive care’s significance stems from ketamine’s advanced pharmacology. Whereas ketamine primarily acts as an NMDA receptor antagonist, it additionally interacts with opioid receptors, monoaminergic transporters, and voltage-sensitive calcium channels. This multifaceted mechanism of motion makes the event of a single, universally efficient reversal agent difficult. Traditionally, clinicians have relied on cautious monitoring and focused interventions to mitigate undesirable results.
